Acknowledging the unwavering support of her loved ones, especially her daughter, Christina Applegate recently opened up about the uncertainties surrounding her acting career following her multiple sclerosis diagnosis two years ago. During her acceptance speech for the TV Legacy Award at Variety's TV Fest, Applegate hinted at the challenges she faces, drawing parallels to her Hollywood Walk of Fame star acceptance last fall.

Expressing gratitude for the understanding she's received, Applegate admitted to not knowing if she'll act again. She confessed to deeply missing the craft but acknowledged the daily physical struggles she endures. She expressed gratitude for concluding her on-screen work with the Netflix series "Dead to Me," which finished filming in 2022.

Applegate voiced concerns about the logistical challenges of working on set with her physical limitations. She questioned her ability to manage the demands of a production environment and establish necessary boundaries to accommodate her condition. The cast and crew of "Dead to Me" provided invaluable support, even holding her legs off-camera when her balance faltered. She praised their compassion and understanding, unsure if she would find such a supportive team again.

Applegate's MS battle has significantly impacted her life and career. (Gilbert Flores/Variety)

The "Dead to Me" crew implemented creative solutions to support Applegate during filming. (Saeed Adyani/Netflix)

Rewatching "Dead to Me" is difficult for Applegate, as it brings back the physical pain she experienced during filming. However, she recognizes the show's artistic merit and expresses gratitude to director Liz Feldman for believing in her. She also praised her co-star, Linda Cardellini, calling her the ideal partner for the project.

Applegate celebrated her Hollywood Walk of Fame star with Cardellini by her side. (Phillip Faraone)

While her acting future remains uncertain, Applegate is exploring alternative creative avenues, such as voice acting and podcasting.